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Ritonavir or lopinavir/ritonavir significantly boost plasma concentrations of oxycodone in healthy human volunteers as a result of inhibition of CYP3A4 and CYP2D6.[58] Rifampicin enormously minimizes plasma concentrations of oxycodone as a result of robust induction of CYP3A4.Take this medication just as prescribed to lower the risk of habit. Reque